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KMID : 0043320180410050513
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Archives of Pharmacal Research
2018 Volume.41 No. 5 p.513 ~ p.518
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Two new β-carboline alkaloids from the stems of Picrasma quassioides
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Kwon Hyun-Sook
Lee Han-Na
Lee Jin-Su
Lee Ki-Jun
Choi Jung-Hye
Jang Dae-Sik
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Abstract
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Two new β-carboline alkaloids, 1-acetyl-4-methoxy-8-hydroxy-β-carboline (1) and 1-acetyl-4,8-dimethoxy-β-carboline (2), together with 10 known compounds; seven β-carboline alkaloids (3?9), two canthin-6-one alkaloids (10 and 11), and one quassinoid (12) were isolated from the stems of Picrasma quassioides. The structure of the new compounds 1 and 2 were determined by spectroscopic analyses including 1D- and 2D-NMR and HRMS interpretation. All the isolates (1?12) were evaluated for their cytotoxicity against human ovarian carcinoma A2780 and SKOV3 cell lines using MTT assays. Of the isolates, compounds 5?7 exhibited the most potent cytotoxicity on both A2780 and SKOV3 cell lines in vitro.
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KEYWORD
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Picrasma quassioides, Simaroubaceae, β-Carboline alkaloids, Cytotoxicity, Ovarian cancer cell
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